Author/Authors :
Bernard Cimetière، نويسنده , , Thierry Dubuffet، نويسنده , , Caroline Landras، نويسنده , , Jean-Jacques Descombes، نويسنده , , Serge Simonet، نويسنده , , Tony J. Verbeuren، نويسنده , , Gilbert Lavielle، نويسنده ,
Abstract :
A pyridine group was linked to the tetrahydronaphthalene moiety of the derivatives described in the preceding paper, to afford new combined thromboxane receptor (TP-receptor) antagonists and synthase inhibitors. The most interesting compound inhibits TXA2 synthase with an IC50 value of 0.64 μM and the aggregation of human platelets with an IC50 value of 0.063 μM and shows a long duration of action in different species after oral administration.
