Author/Authors :
Yasuo Koga، نويسنده , , Yoshito Kihara، نويسنده , , Minoru Okada، نويسنده , , Yoshihiro Inoue، نويسنده , , Shirou Tochizawa، نويسنده , , Kazuyuki Toga، نويسنده , , Kazue Tachibana، نويسنده , , Yukio Kimura، نويسنده , , Takao Nishi MD، نويسنده , , Hiroyoshi Hidaka and Walter J Chazin، نويسنده ,
Abstract :
In order to search for anti-arteriostenotic agents, a series of 2(1H)-quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (−)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2(1H)-quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia.
