Title of article :
Synthesis and anti-HIV activities of urea-pETT analogs belonging to a new class of potent non-nucleoside HIV-1 Reverse transcriptase inhibitors
Author/Authors :
Christer Sahlberg، نويسنده , , Rolf Noréen، نويسنده , , Per Engelhardt، نويسنده , , Marita H?gberg، نويسنده , , Jussi Kangasmets?، نويسنده , , Lotta Vrang، نويسنده , , Hong Zhang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
6
From page :
1511
To page :
1516
Abstract :
A series of potent specific HIV-1 RT inhibitory compounds is described. The compounds are urea analogs of PETT ( henyl thyl hiazole hiourea) derivatives and the series includes derivatives with an ethyl linker (1–6) and conformationally restricted analogs (7–13). The antiviral activity is determined both at the RT level and in cell culture on both native and mutant forms of HIV-1. Many compounds display activity in the nM range against wt-RT.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
1998
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
789462
Link To Document :
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