Author/Authors :
H. N. Shroff، نويسنده , , C. F. Schwender، نويسنده , , A. D. Baxter، نويسنده , , F. Brookfield، نويسنده , , L. J. Payne، نويسنده , , N. A. Cochran، نويسنده , , D. L. Gallant، نويسنده , , M. J. Briskin، نويسنده ,
Abstract :
MAdCAM-1 specifically binds the lymphocyte integrin α4β7 and participates in the homing of leukocytes to intestinal mucosal sites. The LDT sequence located on the CD loop of MAdCAM-1 is an important binding site for MAdCAM-1/α4β7 interactions. N-Terminus acylation of the LDT motif and modification of the C-terminus carboxamide with amines led to low micromolar MAdCAM-1 inhibitors.
