Author/Authors :
Kye Jung Shin، نويسنده , , Kyung Ho Yoo، نويسنده , , Dong Jin Kim، نويسنده , , Sang Woo Park، نويسنده , , Bong Suck Ko، نويسنده , , Sang Joo Lee، نويسنده , , Jae Doo Huh، نويسنده , , Seung-Yong Park، نويسنده ,
Abstract :
The synthesis and biological activity of the novel series of 1β-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2=NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety.
