Title of article
Synthesis and biological properties of new 1β-methylcarbapenems
Author/Authors
Kye Jung Shin، نويسنده , , Kyung Ho Yoo، نويسنده , , Dong Jin Kim، نويسنده , , Sang Woo Park، نويسنده , , Bong Suck Ko، نويسنده , , Sang Joo Lee، نويسنده , , Jae Doo Huh، نويسنده , , Seung-Yong Park، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1607
To page
1612
Abstract
The synthesis and biological activity of the novel series of 1β-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2=NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789481
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