Author/Authors :
Angela Lombardi، نويسنده , , Bruno DʹAgostino، نويسنده , , Amelia Filippelli، نويسنده , , Carlo Pedone، نويسنده , , Maria Gabriella Matera، نويسنده , , Maddalena Falciani، نويسنده , , Mario De Rosa، نويسنده , , Francesco Rossi، نويسنده , , Vincenzo Pavone، نويسنده ,
Abstract :
We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN 10627.
