Title of article :
A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P3 and its effect on Cl−-secretion from T84 cells
Author/Authors :
Marco T. Rudolf، نويسنده , , Alexis E. Traynor-Kaplan، نويسنده , , Carsten Schultz، نويسنده ,
Abstract :
The synthesis of rac-2,5,6-tri-O-butyryl-myo-inositol 1,3,4-trisphosphate hexakis(acetoxymethyl) ester [Bt3-Ins(1,3,4)P3/AM, 1], a membrane-permeant derivative of myo-inositol 1,3,4-trisphosphate [Ins(1,3,4)P3] is reported. 1 inhibited calcium-mediated chloride secretion of T84 cells, suggesting a regulatory link of Ins(1,3,4)P3 and the biosynthesis of the known inhibitor myo-inositol 3,4,5,6-tetrakisphosphate.
