Title of article :
The novel cyclopropapyrroloindole(CPI) bisalkylators bearing 3,3′-(1,4-phenylene)diacryloyl group as a linker
Author/Authors :
Yasumichi Fukuda، نويسنده , , Shigeki Seto، نويسنده , , Hirosuke Furuta، نويسنده , , Hiroyuki Ebisu، نويسنده , , Yasuo Oomori، نويسنده , , Shiro Terashima، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
The novel cyclopropapyrroloindole(CPI) bisalkylators were synthesized and their antitumor activity was evaluated. Among these derivatives, AT-760 (5a) in which the two 3-methoxycarbonyl-2-trifluoromethylCPI (MCTFCPI) moieties are connected with a 3,3′-(1,4-phenylene)diacryloyl group, was found to exhibit more prominent cytotoxicity and antitumor activity than U-77,779 (bizelesin) (1).
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
