Title of article
Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists
Author/Authors
David J. Wustrow، نويسنده , , Thomas Capiris، نويسنده , , Ronald Rubin، نويسنده , , James A. Knobelsdorf، نويسنده , , Hyacinth Akunne، نويسنده , , M. Duff Davis، نويسنده , , A. ROBERT MACKENZIE ، نويسنده , , Thomas A. Pugsley، نويسنده , , Kim T. Zoski، نويسنده , , Thomas G. Heffner، نويسنده , , Lawrence D. Wise، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
2067
To page
2070
Abstract
A series of 3-phenylpyrazolo[1,5-a]pyrimidines was prepared and found to have affinity for the human CRF-1 receptor. The 3-dimensional structure of one of the most potent analogs in this series, 10d, was determined by X-ray crystallography and suggests the spatial requirements for potent CRF-1 receptor binding affinity in this series.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789571
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