Author/Authors :
David J. Wustrow، نويسنده , , Thomas Capiris، نويسنده , , Ronald Rubin، نويسنده , , James A. Knobelsdorf، نويسنده , , Hyacinth Akunne، نويسنده , , M. Duff Davis، نويسنده , , A. ROBERT MACKENZIE ، نويسنده , , Thomas A. Pugsley، نويسنده , , Kim T. Zoski، نويسنده , , Thomas G. Heffner، نويسنده , , Lawrence D. Wise، نويسنده ,
Abstract :
A series of 3-phenylpyrazolo[1,5-a]pyrimidines was prepared and found to have affinity for the human CRF-1 receptor. The 3-dimensional structure of one of the most potent analogs in this series, 10d, was determined by X-ray crystallography and suggests the spatial requirements for potent CRF-1 receptor binding affinity in this series.
