Author/Authors :
Mark A. Massa، نويسنده , , William C. Patt، نويسنده , , Kyunghye Ahn، نويسنده , , Andre M. Sisneros، نويسنده , , Sarah B. Herman، نويسنده , , Annette Doherty، نويسنده ,
Abstract :
A series of bi-aryl pyridine carboxylic acids has been prepared and evaluated as inhibitors of ECE-1. The analogs were prepared by Pd catalyzed cross couplings of halogenated pyridines with heteroaryl organo-boranes, -tinate or -zincate derivatives.