Title of article
Synthesis and biological activity of 2-methyl-20-epi analogues of 1α,25-dihydroxyvitamin D3
Author/Authors
Toshie Fujishima، نويسنده , , Zhaopeng Liu، نويسنده , , Daishiro Miura، نويسنده , , Manabu Chokki، نويسنده , , Seiichi Ishizuka، نويسنده , , Katsuhiro Konno، نويسنده , , Hiroaki Takayama، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
2145
To page
2148
Abstract
Synthesis and biological evaluation of all eight possible A-ring diastereomers of 2-methyl-20-epi-1,25-dihydroxyvitamin D3 are described. Among the analogues synthesized, 2α-methyl-20-epi-1α,25-dihydroxyvitamin D3 exhibited exceptionally high potency. The double modification of 2-methyl substitution and 20-epimerization yielded analogues with unique activity profiles.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789586
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