Author/Authors :
Toshie Fujishima، نويسنده , , Zhaopeng Liu، نويسنده , , Daishiro Miura، نويسنده , , Manabu Chokki، نويسنده , , Seiichi Ishizuka، نويسنده , , Katsuhiro Konno، نويسنده , , Hiroaki Takayama، نويسنده ,
Abstract :
Synthesis and biological evaluation of all eight possible A-ring diastereomers of 2-methyl-20-epi-1,25-dihydroxyvitamin D3 are described. Among the analogues synthesized, 2α-methyl-20-epi-1α,25-dihydroxyvitamin D3 exhibited exceptionally high potency. The double modification of 2-methyl substitution and 20-epimerization yielded analogues with unique activity profiles.
