A dipyrido [2,3-b:3′,2′-f]azepine analog of the HIV-1 reverse transcriptase inhibitor nevirapine

The syntheses of 11-ethyl and 11-cyclopropyldipyrido[2,3-b:3′,2′-f]azepines, analogs of the HIV-1 reverse transcriptase inhibitor nevirapine 1, are described. These compounds exhibit potency equivalent to nevirapine in the inhibition of wild-type and some mutant RT enzymes.