Title of article :
In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI
Author/Authors :
Ze-Qi Xu، نويسنده , , Robert W. Buckheit Jr.، نويسنده , , Tracy L. Stup، نويسنده , , Michael T. Flavin، نويسنده , , Albert Khilevich، نويسنده , , John D. Rizzo، نويسنده , , Lin Lin، نويسنده , , David E. Zembower، نويسنده ,
Abstract :
The three chromanone derivatives, (+)-, (−)-, and (±)-12-oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV). The compounds were determined to be inhibitors of HIV-1 reverse transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.
