Title of article
Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors
Author/Authors
Brad O. Buckman، نويسنده , , Raju Mohan، نويسنده , , Sunil Koovakkat، نويسنده , , Amy Liang، نويسنده , , Lan Trinh، نويسنده , , Michael M. Morrissey، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2235
To page
2240
Abstract
The synthesis of amidinoaryloxy 9-benzyl-8-methyl-9H-purine, 7,8-dihydropteridine-6(5H)-one and 5,7-dihydropyrimido[4,5-b][1,4]oxazine-6-one inhibitors of Factor Xa is described. These compounds show nanomolar potency against FXa and maintain high selectivity over thrombin and trypsin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789604
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