Title of article
A photoactivated prodrug
Author/Authors
Yaoming Wei، نويسنده , , Yinfa Yan، نويسنده , , Dehua Pei and Wim G. J. Hol، نويسنده , , Bing Gong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
2419
To page
2422
Abstract
A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyuridine (2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (λ = 350 nm) resulted in potent inhibition of cell growth.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789637
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