Title of article
N-carbamoyl analogs of zafirlukast: Potent receptor antagonists of leukotriene D4
Author/Authors
Matthew F. Brown، نويسنده , , Anthony Marfat، نويسنده , , Gerard Antognoli، نويسنده , , Robert J. Chambers، نويسنده , , John B. Cheng، نويسنده , , David B. Damon، نويسنده , , Theodore E. Liston، نويسنده , , Molly A. McGlynn، نويسنده , , Stacie P. OʹSullivan، نويسنده , , Brian S. Owens، نويسنده , , Joann S. Pillar، نويسنده , , John T. Shirley، نويسنده , , John W. Watson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2451
To page
2456
Abstract
Exploration of the indole nitrogen region of Zafirlukast (1) has uncovered a potent series of cysteinyl leukotriene D4 (LTD4) antagonists. These studies showed that a variety of functionality could be incorporated in this region of the molecule without sacrificing potency. Efforts to exploit this site in order to improve oral efficacy are discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789644
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