Title of article
Synthesis and effects of novel thiazole derivatives against thrombocytopenia
Author/Authors
Kiyoshi Tsuji، نويسنده , , Takashi Ogino، نويسنده , , Nobuo Seki، نويسنده , , Masae Sawada، نويسنده , , Yu Sudo، نويسنده , , Fusako Nishigaki، نويسنده , , Toshitaka Manda، نويسنده , , Massaki Matsuo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2473
To page
2478
Abstract
5-(2-Pyridylsulfonyl)-2-thiazolamine (2) was effective both in mitomycin C (MMC)-induced thrombocytopenia and in an animal model of idiopathic thrombocytopenic purpura (ITP). It also suppressed the increase of autoantibodies against platelets in the ITP model and showed no blood toxicity. Chemical modification of 2 led to the discovery of more potent compounds against MMC-induced thrombocytopenia.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789648
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