Author/Authors :
James L. Bullington، نويسنده , , Julie C. Cameron، نويسنده , , Janet E. Davis، نويسنده , , John H. Dodd، نويسنده , , Crafford A. Harris، نويسنده , , James R. Henry، نويسنده , , J. Lee Pellegrino-Gensey، نويسنده , , Kenneth C. Rupert، نويسنده , , John J. Siekierka، نويسنده ,
Abstract :
Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56lck, is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56lck.
