Title of article
Nα-alkylated derivatives of 2-phenylhistamines: Synthesis and in vitro activity of potent histamine H1-receptor agonists
Author/Authors
K. Kramer، نويسنده , , S. Elz، نويسنده , , H. H. Pertz، نويسنده , , W. Schunack، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2583
To page
2588
Abstract
New potent Nα-alkylated histamine H1-receptor agonists have been prepared and functionally evaluated for partial agonist potency and selectivity. Nα-Methyl-2-(3-trifluoromethylphenyl)histamine contracts ileal segments and aortic rings of guinea-pig with a relative potency of 174% (95% confid. lim. 161 – 188%) and 217% (164 – 287%), respectively (histamine: 100%) and is the most potent H1 receptor agonist described so far.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789669
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