Author/Authors :
Montse Llinàs-Brunet، نويسنده , , Murray Bailey، نويسنده , , Robert Déziel، نويسنده , , Gulrez Fazal، نويسنده , , Vida Gorys، نويسنده , , Sylvie Goulet، نويسنده , , Ted Halmos، نويسنده , , Roger Maurice، نويسنده , , Martin Poirier، نويسنده , , Marc-André Poupart، نويسنده , , Jean Rancourt، نويسنده , , Diane Thibeault، نويسنده , , Dominik Wernic، نويسنده , , Daniel Lamarre، نويسنده ,
Abstract :
Replacememt of the C-terminal carboxylic acid functionality of peptide inhibitors of hepatitis C virus (HCV) NS3 protease (complexed with NS4A peptide cofactor) by activated carbonyl groups does not produce any substantial increase in potency. These latter inhibitors also inhibit a variety of other serine and cysteine proteases whereas the carboxylic acids are specific. Norvaline was identified as a chemically stable replacement for the P1 residue of Ac-DDIVPC-OH which was also compatible with activated carbonyl functionalities.
