Title of article
Conformationally constrained inhibitors of caspase-1 (interleukin-1β converting enzyme) and of the human ced-3 homologue caspase-3 (CPP32, apopain)
Author/Authors
Donald S. Karanewsky، نويسنده , , Xu Bai، نويسنده , , Steven D. Linton، نويسنده , , Joseph F. Krebs، نويسنده , , Joe Wu، نويسنده , , Bryan Pham، نويسنده , , Kevin J. Tomaselli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2757
To page
2762
Abstract
A systematic study of interleukin-1β converting enzyme (ICE, caspase-1) and caspase-3 (CPP32, apopain) inhibitors incorporating a P2–P3 conformationally constrained dipeptide mimetic is reported. Depending on the nature of the P4 substituent, highly selective inhibitors of both Csp-1 or Csp-3 were obtained.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789701
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