Author/Authors :
Alan X. Wang، نويسنده , , Qinghua Xie، نويسنده , , Ben Lane، نويسنده , , Karl W. Mollison، نويسنده , , Gin C. Hsieh، نويسنده , , Kennan Marsh، نويسنده , , Michael P. Sheets، نويسنده , , Jay R. Luly، نويسنده , , Michael J. Coghlan، نويسنده ,
Abstract :
A series of novel pyrazole carboxamides is disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50< 1 μM). The synthesis, biological activity, mode of action, and pharmacokinetic properties of this new lead series are discussed.
