Title of article
Design and synthesis of dipeptidyl α′,β′-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain
Author/Authors
William R. Roush.، نويسنده , , Florenci V. Gonz?lez، نويسنده , , Andrej Sali and James H. McKerrow، نويسنده , , Elizabeth Hansell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
2809
To page
2812
Abstract
The dipeptidyl epoxy ketone 4 is a potent, irreversible inhibitor of cruzain, a cysteine protease isolated from Trypanosoma cruzi, with an apparent second order inhibition rate constant of 330,000 sec−1M−1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789711
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