Title of article
Design and synthesis of a pyridone-based phosphotyrosine mimetic
Author/Authors
Jian-Min Fu، نويسنده , , Arlindo L. Castelhano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
2813
To page
2816
Abstract
A novel pyridone-based tyrosine analog, 6, has been designed to mimic the binding interaction of SH2 domains with phosphotyrosine (pTyr) containing peptides. Synthesis of 6 features a key Pd catalyzed coupling of β-iodoalanine with phosphonomethyl 4-pyridone triflate.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789712
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