Title of article :
In vitro inhibitory effects of DNA topoisomerase II by fernane-type triterpenoids isolated from a Euphorbia genus
Author/Authors :
Shun-ichi Wada، نويسنده , , Reiko Tanaka، نويسنده , , Akira Iida، نويسنده , , Shunyo Matsunaga، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
Several kinds of naturally occurring fernane-type triterpenoids isolated from a Euphorbia genus were tested on the inhibitory effects of DNA Topoisomerases I (Topo I) and II (Topo II) activities. A-ring cleaved 3,4-sero-8βH-ferna-4(23),9(11)-dien-3-oic acid and its 3-hydroxyl derivative were found to be selective inhibitors of Topo II activity without the stabilization of a DNA/Topo II cleavable complex.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
