Author/Authors :
Hideto Fukui، نويسنده , , Tetsuo Shibata، نويسنده , , Takanobu Naito، نويسنده , , Jun Nakano، نويسنده , , Tetsuro Maejima، نويسنده , , Hisato Senda، نويسنده , , Wakao Iwatani، نويسنده , , Yoshiyuki Tatsumi، نويسنده , , Masahiro Suda، نويسنده , , Ta-i Arika، نويسنده ,
Abstract :
The titled compounds were synthesized and evaluated for in vitro antibacterial activity. The (3R,4S)-3-aminomethyl-4-trifluoromethyl derivative (S-34109) was confirmed to be optimal because of its superior activity against quinolone and methicillin-resistant Staphyrococcus aureus and low side effect potential.
