Title of article
Synthesis and antiproliferative activity of a cyclic analog of dolastatin 10
Author/Authors
Joël Poncet، نويسنده , , Laurent Hortala، نويسنده , , Magali Busquet، نويسنده , , Françoise Guéritte-Voegelein، نويسنده , , Sylvie Thoret، نويسنده , , Alain Pierré، نويسنده , , Ghanem Atassi، نويسنده , , Patrick Jouin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
2855
To page
2858
Abstract
A cyclic analog of the natural antiproliferative compound dolastatin 10 was synthesized by introducing an ester link between the N- and C-terminal residues which were modified accordingly. The final macrolactonization was performed by using isopropenyl chloroformate and DMAP as reagents. This analog exhibits submicromolar antiproliferative activity against the L1210 and HT29 cell lines and inhibits in vitro tubulin polymerization (IC50, 39 μM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789720
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