Title of article
Fused aminotetralins: novel antagonists with high selectivity for the dopamine D3 receptor
Author/Authors
Kim Y. Avenell، نويسنده , , Izzy Boyfield، نويسنده , , Martyn C. Coldwell، نويسنده , , Michael S. Hadley، نويسنده , , Maureen A. M. Healy، نويسنده , , Philip M. Jeffrey، نويسنده , , Christopher N. Johnson، نويسنده , , David J. Nash، نويسنده , , Graham J. Riley، نويسنده , , Emma E. Scott، نويسنده , , Stephen A. Smith، نويسنده , , Rachel Stacey، نويسنده , , Geoffrey Stemp، نويسنده , , Kevin M. Thewlis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
2859
To page
2864
Abstract
Starting from a series of 2-aminotetralins 1, a novel series of N-[4-(4-phenylbenzoylamino)butyl]-octahydrobenzoquinolines and hexahydrobenzoindoles with high potency and selectivity for the dopamine D3 receptor has been designed. The effect of ligand chirality on binding affinity has been established. Selected derivatives (e.g. 2o, 2p) show high functional selectivity and enhanced in vivo properties compared to 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789721
Link To Document