Author/Authors :
Antonio Guarna، نويسنده , , Ernesto G. Occhiato، نويسنده , , Dina Scarpi، نويسنده , , Ruey Tsai، نويسنده , , Giovanna Danza، نويسنده , , Alessandra Comerci، نويسنده , , Rosa Mancina، نويسنده , , Mario Serio، نويسنده ,
Abstract :
A short and efficient synthesis of novel benzo[c]quinolizin-3-one derivatives is described. The synthesis is based on the tandem Mannich-Michael cyclization between 2-silyloxy-1,3-butadienes and a N-t-Boc iminium ion. The prepared derivatives are selective inhibitors of human steroid 5α-reductase isoenzyme 1, thus having potential application as drugs for treatment of male pattern baldness and other DHT-dependent skin disorders.
