Title of article :
First synthesis of alternating SATE-phosphotriester/ phosphodiester prooligonucleotides on solid support
Author/Authors :
Guilhem Tosquellas، نويسنده , , Jean Charles Bologna، نويسنده , , François Morvan، نويسنده , , Bernard Rayner، نويسنده , , Jean-Louis Imbach، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
Prooligonucleotides with alternating S-Acyl-ThioEthyl (SATE) phosphotriester and phosphodiester linkages or a gap were synthesized by elimination of cyanoethyl group with non-nucleophilic base DBU. Their half-lives in the presence of Pig Liver Esterases (PLE) and in total cell extract were determined.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
