Title of article :
Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid
Author/Authors :
Pier Giovanni Baraldi، نويسنده , , Barbara Cacciari، نويسنده , , Andrea Guiotto، نويسنده , , Alberto Leoni، نويسنده , , Romeo Romagnoli، نويسنده , , Giampiero Spalluto، نويسنده , , Nicola Mongelli، نويسنده , , Philip W. Howard، نويسنده , , David E. Thurston، نويسنده , , Nicoletta Bianchi، نويسنده , , University of Perugia
Roberto Gambari، نويسنده ,
Abstract :
We report the synthesis of a new hybrid 13 which is a combination of the naturally occurring antitumor agent distamycin A 1 and the pyrrolo[2,1-c][1,4]benzodiazepine 11, related to the naturally occurring anthramycin 2. The antitumor activity of the hybrid 13 was tested in vitro and compared to the natural product distamycin 1 and the PBD 11.
