Title of article
Structural determinants of substrates and inhibitors: probing glutamate transporters with 2,4-methanopyrroldidine-2,4-dicarboxylate
Author/Authors
C. Sean Esslinger، نويسنده , , Hans P. Koch، نويسنده , , Michael P. Kavanaugh، نويسنده , , Dean P. Philips، نويسنده , , A. Richard Chamberlin، نويسنده , , Charles M. Thompson، نويسنده , , Richard J. Bridges، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
3101
To page
3106
Abstract
Using an intramolecular [2+2] photocyclization 2,4-methanopyrrolidine-2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that differentiate substrate and non-substrate inhibitors of a high-affinity, sodium-dependent glutamate transporter.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789768
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