Author/Authors :
Carolyn DiIanni Carroll، نويسنده , , Theodore O. Johnson، نويسنده , , Shewei Tao، نويسنده , , Giorgio Lauri، نويسنده , , Marc Orlowski، نويسنده , , Ilya Y. Gluzman، نويسنده , , Daniel E. Goldberg، نويسنده , , Roland E. Dolle، نويسنده ,
Abstract :
A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P1′, P2–P4 surrogates. Evaluation of this encoded library against two aspartyl proteases, plasmepsin II and cathepsin D, led to the identification of selective inhibitors for each enzyme.
