Author/Authors :
Toshihiro Hatanaka، نويسنده , , Koichi Fujita، نويسنده , , Koji Ohsumi، نويسنده , , Ryusuke Nakagawa، نويسنده , , Yumiko Fukuda، نويسنده , , Yukio Nihei، نويسنده , , Yasuyo Suga، نويسنده , , Yukio Akiyama، نويسنده , , Takashi Tsuji، نويسنده ,
Abstract :
A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative (19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility.
