Author/Authors :
Kazuya Yoshiizumi، نويسنده , , Norihiko Seko، نويسنده , , Noriyasu Nishimura، نويسنده , , Shoji Ikeda، نويسنده , , Kohichiro Yoshino، نويسنده , , Hirosato Kondo، نويسنده , , Kazutaka Tanizawa، نويسنده ,
Abstract :
To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.
