Title of article :
Novel cytotoxic diterpenes from the stem of dysoxylum kuskusense
Author/Authors :
Toshihiro Fujioka، نويسنده , , Miyako Yamamoto، نويسنده , , Yoshiki Kashiwada، نويسنده , , Hiroko Fujii، نويسنده , , Kunihide Mihashi، نويسنده , , Yasumasa Ikeshiro، نويسنده , , Ih-Sheng Chen، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
Three novel diterpenes, dysokusones A (1), B (2), and C (3), were isolated from the stem of Dysoxylum kuskusense as cytotoxic substances. The structures were established by spectroscopic examinations. Compounds 1, 2, and 3 were cytotoxic toward HL-60(TB) cells with EC50 values of 2.25, 6.35, and 2.37 μM, respectively. Compound 1 also displayed cytotoxicity against K-562 and NCI-H522 cells with EC50 values of 5.04 and 4.80 μM, respectively.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
