Author/Authors :
Jeewoo Lee، نويسنده , , Mee Kyoung Kang، نويسنده , , Moon Woo Chun and، نويسنده , , Yeong Joon Jo، نويسنده , , Jin Hwan Kwak، نويسنده , , Sunghoon Kim، نويسنده ,
Abstract :
A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, -methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with Ki = 19 μM and showed a growth inhibition against E.coli JM 109, P. vulganis 6059 and C. freundii 8090.
