Author/Authors :
Anne Cosquer، نويسنده , , Vianney Pichereau، نويسنده , , Didier Le Mée، نويسنده , , Myriam Le Roch، نويسنده , , Jacques Renault، نويسنده , , Bertrand Carboni، نويسنده , , Philippe Uriac، نويسنده , , Théophile Bernard، نويسنده ,
Abstract :
Seven analogues of the bacterial osmoprotectant glycine betaine (GB, trimethylammonioacetate), in which the methyl groups of the Me3N+ moiety are replaced by various substituents, were obtained by SPOS using Wang resin. Their biological activities (osmoprotection vs toxicity), appeared closely related to their uptake efficiency and their catabolism in the betaine-demethylating model bacterium Sinorhizobium meliloti.
