Author/Authors :
Chuan Shih، نويسنده , , Lynn S. Gossett، نويسنده , , Joseph M. Gruber، نويسنده , , C. Sue Grossman، نويسنده , , Sherri L. Andis، نويسنده , , Richard M. Schultz، نويسنده , , John F. Worzalla، نويسنده , , Tom H. Corbett، نويسنده , , James T. Metz، نويسنده ,
Abstract :
Structure modification of the β-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (β-alanine) with various (1)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.
