Author/Authors :
Dong-Ick Kim، نويسنده , , Hak-Yeop Kim، نويسنده , , Lae-Sung Kwon، نويسنده , , Sung-Dae Park، نويسنده , , Gee-Ho Jeon، نويسنده , , Kyung-Yun Jung، نويسنده , , Jae-Ki Min، نويسنده , , Woong-Hyun Nam، نويسنده , , Kiho Lee، نويسنده , , Dong-Sup Chung، نويسنده , , Shigeru Tanabe، نويسنده , , Toshiro Kozono، نويسنده ,
Abstract :
A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc) and action potential duration (APD) in isolated guinea-pig papillary muscles at 1 Hz and 3 Hz were examined. SAR studies led to the identification of KCB-328 (51) which is a novel class III antiarrhythmic agent with little reverse frequency dependence.
