Title of article
Synthesis and biological activity of KCB-328 and its analogues: Novel class III antiarrhythmic agents with little reverse frequency dependence
Author/Authors
Dong-Ick Kim، نويسنده , , Hak-Yeop Kim، نويسنده , , Lae-Sung Kwon، نويسنده , , Sung-Dae Park، نويسنده , , Gee-Ho Jeon، نويسنده , , Kyung-Yun Jung، نويسنده , , Jae-Ki Min، نويسنده , , Woong-Hyun Nam، نويسنده , , Kiho Lee، نويسنده , , Dong-Sup Chung، نويسنده , , Shigeru Tanabe، نويسنده , , Toshiro Kozono، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
85
To page
90
Abstract
A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc) and action potential duration (APD) in isolated guinea-pig papillary muscles at 1 Hz and 3 Hz were examined. SAR studies led to the identification of KCB-328 (51) which is a novel class III antiarrhythmic agent with little reverse frequency dependence.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789898
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