Title of article
Isoxazoline GPIIb/IIIa antagonists bearing a phosphoramidate
Author/Authors
John Wityak، نويسنده , , A. Ewa Tobin، نويسنده , , Shaker A. Mousa، نويسنده , , Ruth R. Wexler، نويسنده , , Richard E. Olson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
123
To page
126
Abstract
Isoxazolinylacetamides bearing a phosphoramidate group α- to the carboxylate moiety (3) were prepared and evaluated for in vitro antiplatelet efficacy. They were found to bind GPIIb/IIIa with high affinity and were potent antagonists of ADP mediated platelet aggregation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789905
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