Title of article :
In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones
Author/Authors :
Masami Kawase، نويسنده , , Hiromi Harada، نويسنده , , Setsuo Saito، نويسنده , , Jiongmo Cui، نويسنده , , Satoru Tani، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Abstract :
Heteroaromatic trifluoromethyl ketones (TFMKʹs) showed strong inhibitory activity against Helicobacter pylori. The MIC50 observed for 2-trifluoroacetonylbenzoxazole (1) is 20-fold more active than metronidazole and is only twice as high as that of clarithromycin. The inhibitory mode of TFMKʹs on Hp growth was not related to inhibition of urease.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
