Author/Authors :
Cynthia A. Fink، نويسنده , , J. Eric Carlson، نويسنده , , Charles Boehm، نويسنده , , Patricia McTaggart، نويسنده , , Ying Qiao، نويسنده , , John Doughty، نويسنده , , Vishwas Ganu، نويسنده , , Richard Melton، نويسنده , , Ronald Goldberg، نويسنده ,
Abstract :
A series of thiol containing derivatives was prepared. Several of these compounds were found to inhibit matrix metalloproteinases 1, 3, and 9 with selectivity towards 3 and 9. Compounds 15, 20, and 22 were administered to rats orally at 75 μmol/kg. Drug levels of compounds 20 and 22 in the plasma were found to exceed the IC50 values for MMP 3 and 9 four hours after administration.
