Author/Authors :
Yves P. Auberson، نويسنده , , Pierre Acklin، نويسنده , , Serge Bischoff، نويسنده , , Robert Moretti، نويسنده , , Silvio Ofner، نويسنده , , Markus Schmutz، نويسنده , , Siem J. Veenstra، نويسنده ,
Abstract :
N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine-binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsant effects in the electroshock-induced convulsion assay in mice.
