Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases
Author/Authors :
Xiang Y. Yu، نويسنده , , Jason M. Hill، نويسنده , , Guixue Yu، نويسنده , , Weiheng Wang، نويسنده , , Arthur F. Kluge، نويسنده , , Phil Wendler، نويسنده , , Paul Gallant، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
6
From page :
375
To page :
380
Abstract :
A series of novel aminoacyl adenylate mimics has been prepared and evaluated for their inhibitory activity against aminoacyl-tRNA synthetases. Several of these thiazole derivatives displayed potent and selective enzyme activity against both Gram-positive and Gram-negative bacteria.
