Title of article
Design, synthesis, and evaluation of azapeptides as substrates and inhibitors for human rhinovirus 3C protease
Author/Authors
Shankar Venkatraman، نويسنده , , Jian-she Kong، نويسنده , , Sanjay Nimkar، نويسنده , , Q. May Wang، نويسنده , , Jeffrey Aubé، نويسنده , , Robert P. Hanzlik، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
577
To page
580
Abstract
A series of azapeptides was prepared and assessed as inhibitors of the human rhinovirus 3C protease. Boc-VLFaQ-OPh was a slow-turnover substrate that gave transient (ca. 1–2 h) inhibition as it underwent hydrolysis. Boc-VLFaG-OPh gave very slow but essentially irreversible inhibition.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789996
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