Author/Authors :
Michael Roe، نويسنده , , Adrian Folkes، نويسنده , , Philip Ashworth، نويسنده , , Julie Brumwell، نويسنده , , Lal Chima، نويسنده , , Sukhjit Hunjan، نويسنده , , Ian Pretswell، نويسنده , , Wendy Dangerfield، نويسنده , , Hamish Ryder، نويسنده , , Peter Charlton، نويسنده ,
Abstract :
We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described.
