Sialidase inhibitors related to zanamivir: Synthesis and biological evaluation of 4H-pyran 6-ether and ketone
Author/Authors :
Paul W. Smith، نويسنده , , J. Ed Robinson، نويسنده , , Derek N. Evans، نويسنده , , Steven L. Sollis، نويسنده , , Peter D. Howes، نويسنده , , Naimisha Trivedi، نويسنده , , Richard C. Bethell، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
4
From page :
601
To page :
604
Abstract :
Synthesis of 5R-Acetamido-4S-amino-4H-pyran-6R-O-(1-ethyl)propyl and 6R-(1-oxo-2-ethyl)butyl 2-carboxylic acids (4 and 5) and their evaluation as inhibitors of influenza virus sialidase is described. Both compounds showed good inhibitory activity with marked selectivity for influenza A sialidase.
