Title of article
Solid-phase synthesis of novel inhibitors of Farnesyl Transferase
Author/Authors
Amelia Moreno Barber، نويسنده , , Ian R. Hardcastle، نويسنده , , Martin G. Rowlands، نويسنده , , Bernard P. Nutley، نويسنده , , Jonathan H. Marriott، نويسنده , , Michael Jarman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
623
To page
626
Abstract
A novel diphosphate mimic, the 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy group (1), has been employed as the template in the solid-phase synthesis of novel Farnesyl Transferase inhibitors using the Mitsunobu reaction. The most potent inhibitor (farnesyloxy-5-hydroxy-2,3,6-trifluoro-4-nitrobenzene) displayed an IC50 of 6.3 μM versus Farnesyl Transferase.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790006
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