Title of article
Octa- and nonaprenylhydroquinone sulfates, inhibitors of α1,3-fucosyltransferase VII, from an Australian marine sponge Sarcotragus sp
Author/Authors
Toshiyuki Wakimoto، نويسنده , , Atsushi Maruyama، نويسنده , , Shigeki Matsunaga، نويسنده , , Nobuhiro Fusetani، نويسنده , , Katsumi Shinoda، نويسنده , , Peter T. Murphy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
727
To page
730
Abstract
α1,3-Fucosyltransferase (Fuc TVII) is a key enzyme in the biosynthesis of selectin ligands. We have isolated two inhibitors of Fuc TVII from a marine sponge Sarcotragus sp. They were characterized as octa- and nonaprenylhydroquinone sulfates on the basis of spectral data. These compounds inhibited Fuc-TVII with IC50 values of 3.9 and 2.4 μg/mL, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790026
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